b'How Drawtex wound dressing works Advancing the science of wound bed preparation. How Drawtex helps meet the complex challenges of wound bed preparationLevaFiber Technology provides three different types of action. Case Study (I) Case Study (II)This 32-year-old man was admitted to the Trauma ICU with a gunshot wound. He developed a sacral pressure ulcer that wasThis 68-year-old male presented with a venous ulcer that had been present for 35 years. During that time, it had been treated treated with negative pressure wound therapy (NPWT) prior to the decision to use hydroconductive dressings. Multiple layers ofwith a hydrogel dressing covered by short stretch bandaging changed twice weekly. Drawtex was applied directly onto the NecroticNutrients Deleterious Drawtex were changed on alternate days until wound bed preparation was deemed acceptable. The wound initially was coveredwound and short stretch bandaging continued. After 6 days of treatment with Drawtex, the ulcer had decreased in size by 50%.Mechanisms of Action Debris Exudate Bacteria for Biofilm MMPs by debris and slough. After 8 days of treatment with Drawtex, the amount of slough and debris was greatly decreased.Drawtex facilitates effective wound bed preparation.Capillary Action Hydroconductive Action Electrostatic Action Wound bed preparation is the management of a wound in order to accelerate endogenous healing or to facilitate the effectiveness of other therapeutic measures. 3Recent data have been published showing how wound treatment with Drawtex assists with the complex challenges of wound bed preparation 1,4 :Facilitates removal of debrisUsing an advanced pattern-recognition software algorithm* to analyze digital wound images, researchers calculatedBefore After 6 Days wound measurements and analyzed tissue composition of the wound bed. They found: 5Capillary action gives DrawtexHydroconductive action isElectrostatic action occursDrawtex actively draws fluid away from the wound up to 150 cc/hour, retaining its integrity when moist. Case Study (III)its ability to move woundcontrolled by Darcys Law,when the negatively charged Drawtex helps to remove debris from the wound by drawing out fibrin and slough, while leaving healthy granulationBefore After 8 Daysexudate and wound debriswhich defines the ability of aDrawtex wound dressingtissue in place. 5 This female patient had developed a wound after her leg started itching. Skin irritation and scratching caused a small wound that grew larger every day. The wound discharged large volumes of fluid, leading to more scratching by the into the porous material of thefluid to flow through porouscomes into contact with theiCLR Technologypowered by Elixr * patient. Only 24 hours after Drawtex was applied, the itching disappeared completely. The wound bed responded well dressing. With the small poresmedia. Fluid can move fromwound exudate. Ions fromDraws and absorbs excessive wound exudate to the treatment, and the patient experienced no more itching, pain or discomfort.acting as capillaries, inter- wetter to drier, even againstthe exudate form a mobile Another study concluded that the advantages of exudate removal by Drawtex were numerous. Not only was the fluid molecular attractive forcesgravity. This explains howlayer of the opposite chargeremoved, but nutrients in the exudate that facilitate biofilm production were also drawn off. 1,6between the exudate andwater can be transportedknown as the electric double solid surfaces of the woundfrom the roots of a tree tolayer, effectively reversing theDraws bacteria from the wounddressing allow the exudate tothe leaves. The LevaFibercharge on the surface of theA study that evaluated Drawtex in an infected burn model demonstrated that Drawtex can draw methicillin-resistant be drawn upward against theTechnology of Drawtex allowsdressing to become positive.Staphylococcus aureus (MRSA) from either an inoculated broth or an experimental burn wound eschar. 7force of gravity. the dressing to lift, hold, andThis allows the dressing to transfer the wound exudatedraw out a large amountSimilar results were reported in patients with chronic wounds, where tissue biopsy bacterial counts decreased from both vertically and horizontallyof exudate, wound debris,10 6to 10 2CFUs per gram of tissue, while at the same time the bacterial counts in the Drawtex dressings increased by hydroconductive action. bacteria, and harmful MMPs. up to 10 4CFUs. 8Before After 5 DaysDraws harmful MMPs from the wound Before After 8 Days Chronic wounds have excessive inflammation, increased pro-inflammatory cytokines, increased proteases such as 9-11 Case Study (IV)MMPs, and decreased growth factors.Removing or decreasing the harmful MMPs is an important aspect of wound bed preparation. Effect of Drawtex After Eight Days This patient suffered from a severe burn wound for more than a month, with complaints of incapacitating pain and a bad One study reported that Drawtex could draw MMP-9 and transport it for a distance up to 7 cm from the wound. 12 odor. Skin grafting was not possible because the wound bed was badly infected, with high volumes of exudate. Topical Another similar study showed that both MMP-9 and MMP-1 were drawn out of chronic wounds with Drawtex(Granulation) 13% 72% (Granulation) medication along with standard treatment produced very limited success. Drawtex was used along with petrolatum wound dressings, with a concomitant rise in MMPs in the Drawtex dressings. 8 gauze, and after 24 hours the dressings were green with Pseudomonas. By Day 7, the Drawtex treatment had reduced (Slough) 87% the swelling and odor, and blood circulation improved. In addition, enhanced granulation took place, thus creating a healthy wound bed. The wound healed completely within 30 days, and no skin grafting was required.Sets the stage for endogenous healing or wound closure proceduresBased on these mechanisms of action, Drawtex facilitates effective wound bed preparation. 1,2 With Drawtex meeting the goals listed above for wound bed preparation, obstacles to endogenous wound healing or 28% (Slough)wound closure procedures are reduced.(Eschar) 0% 0% (Eschar)08-06-12 8-14-12*iCLR Technology powered by Elixr Drawtex, with its hydroconductive action, lifts and moves exudate, slough, and debris away from the wound surface. Clinical results have shown it todecrease wound exudate, tissue bacterial levels, nutrients for biofilm production, and deleterious cytokine levels such as matrix metalloproteinases (MMP-9). 1,2Based on these actions, Drawtex facilitates effective wound bed preparation and serves as a possible alternative to passive absorptive products, like calcium alginates, *iCLR Technology powered by Elixr is a statistical pattern recognition algorithm that classifies each individual wound color 3 4 Before After 7 Dayshydrofibers, foams, and super absorbers.In addition, at times it can replace some enzymatic, antimicrobial, and negative-pressure wound therapy (NPWT). pixel in a wound image, providing a documented variance of only 1% (with flat wound images).'