b'V A S H EW O U N D S O L U T I O NWhat determines an ideal environmentfor wound healing?THE IMPORTANCE OF pH FOR PROGRESS 10 Dakins solutionThe activity of chlorine-based solutions is dependent upon pH.9 Sodium hypochlorite solutions ChronicLowering the pH to a range of 4-6 results in hypochlorous acidwounds Granulating 8 Blended hypochloriteas the predominant species and a pH that mimics that of intactwoundsand hypochlorous acidhuman skin. As a result, the activity increases by a factor of 80-100Epithelializing PIs-II, & III7 PHMB solutions times that observed in higher-pH solutions such as Dakins solution,woundswhile the lower pH tends to eliminate cytotoxicity and confers6sporicidal activity. 1,2Additional research has confirmed sodium hypochlorite to be cytotoxic at concentrations of 0.0005%, inducingIntact skin 5unnecessary harm to fibroblasts and related cells participating in4Acutethe healing processes. 3 wounds3Chlorine Gas Sodium HypochloriteCytotoxic pH scale100%90% Cl 2 HOCl OCl - The pH of Vashe Wound Solution plays a vital role in the 80% healing environment. In fact, not only does it have an impact 70% V on the antimicrobial efficacy of chlorine in solution, it also has a A positive impact on the pathophysiology associated with positive 60% S cell activity in wounds. Particularly, a review by Nagoba, et al., % Abundance50% H noted that an acidic environment played a role in the 4 :40% E Alteration of protease activity 530% Reduction of toxicity and bacterial end products 620% Support of epithelialization and angiogenesis 7,810% Destruction of abnormal collagen, increase in macrophage and0% 0 2 4 6 8 10 12 14 fibroblast activity, controlling activity of various enzymes pH participating in wound healing 7,9,10STAY IN Vashe Wound Solution, powered by a proprietary THE ZONEelectrochemical process called Natural Zone Technology 5.5, is titrated to a skin-friendly pH WITH maximum of 5.5 to mimic the bodys natural NZT 5.5 antimicrobial defenses and provide an ideal healing environment.TM Our pure hypochlorous acid (HOCl) solution isformulated at a pH of 5.5, the same pH level as healthy, healing skin.Vashe Wound Solution contains the highest concentration of hypochlorous acid of any pure hypochlorous acid wound solution available in the United States.'