b'V A S H EW O U N D S O L U T I O NUse of Vashe for Burns: nfections are the leading cause of morbidity and mortality Iin burn patients, and the use of chlorohexidine, a standard A BALANCED APPROACH TO MANAGING treatment, is limited to intact skin. 34BURN WOUNDSRemoving spores of C. difficile and B. anthracis from skin ischallenging because they are resistant to commonly used Many solutions used in burn centers have strong antimicrobialantimicrobials, and soap and water washing provides only power; however, they also tend to have a high degree ofmodest efficacy. 15cytotoxicity. Vashe has the right balance of the ability to Many topical agents used during burn treatment regimensmechanically remove bacteria and avoidance of cytotoxicitycan be detrimental to the healing process. 35necessary for a burn patient. Vashe demonstrated significant value in its ability to assist with graft take in burn patients,Burn indications for the use of Vashe:while reducing costs. 32Additionally, Vashe is proven to be aIrrigationMoistening Skin GraftsCleansingsuccessful component in universal decontamination protocolsDebridementBed Bathingas the solution for bathing procedures to help assist in the mechanical removal of bacteria in burn patients, contributing to great success in MRSA rate reduction. 33 Vashe Product InformationBottle Size/Pack Size Vashe Wound Solution Vashe Wound Solution forInstillation Applications*4.0 fl. oz. (118 mL) Bottles/24-Pack 00312 Not available8.5 fl. oz. (250 mL) Bottles/12-Pack 00313 0031616.0 fl. oz. (475 mL) Bottles/12-Pack 00314 0031734.0 fl. oz. (1 liter) Bottles/6-Pack 00322 00323References1. Block SS. Disinfection, sterilization, and preservation. Philadelphia: Lea & Febiger; 2000. 2. Wang L, Bassiri M, Najafi R, et al: Hypochlorous acid as a potential wound care agent: Part I. Stabilized hypochlorous acid: A component of the inorganic armamentarium of innate immunity. J Burns Wounds. 2007;6:65-79. 3. Hidalgo E, Bartolome R, Dominguez C. Cytotoxicity mechanisms of sodium hypochlorite in cultured human dermal fibroblasts and its bactericidal effectiveness. Chem Biol Interact. 2002;139(3):265-282. 4. Nagoba BS, Suryawanshi NM, Wadher B, et al. Acidic environment and would healing: A review. Wounds. 2015;27(1):5-11. 5. Vermeulen H, van Hattem JM, Storm-Versloot MN, et al. Topical silver for treating infected wounds. Cochrane Database Syst Rev. 2007;24(1):CD005486. 6. Gethin G. The significance of surface pH in chronic wounds. Wounds UK. 2007;3(3):52-56. 7. Hunt TK, Hopf HW. Wound healing and wound infection: What surgeons and anesthesiologists can do. Surg Clin North Am. 1997;77(3):587-606. 8. Nagoba BS, Gandhi RC, Wadher BJ, et al. Microbiological, histopathological and clinical changes in chronic wounds after citric acid treatment. J Med Microbiol. 2008;57(5):681-682. 9. Thomas S. Wound Management and Dressings. London, UK: Pharmaceutical Press; 1990. 10. Molan PC. Re-introducing honey in the management of wounds and ulcers-theory and practice. Ostomy Wound Manage. 2002;48(11):28-40. 11. Sampson CM, Sampson MN. Hypochlorous acid: A safe and efficacious new wound therapy. Poster presented at: World Union of Wound Healing Societies; 2008; Toronto, Ontario, Canada. 12. Data on file with Urgo Medical North America. 13. Vashe Wound Solution data developed from USP 51 Antimicrobial testing. 14. Bohn GA, Champion S, Eldridge K. Can the use of hypochlorous acid change your dressing selection? Poster Presentation: Symposium for Advanced Wound Care; 2013; Orlando, FL. 15. Nerandzic MM, Rackaityte E, Jury LA, et al. Novel Strategies for Enhanced Removal of Persistent Bacillus anthracis Surrogates and Clostridium difficile Spores from Skin. PLoS One. 2013;8(7):e68706. doi:10.1371/journal.pone.0068706. 16. Tsuda H, Yamashita Y, Shibata Y, et al. Genes involved in bacitracin resistance in Streptococcus mutans. Antimicrob Agents Chemother. 2002;46(12):3756 -3764. 17. Finley PJ, Norton R, Austin C, et al. Unprecedented silver resistance in clinically isolated enterobacteriaceae: Major implications for burn and wound management. Antimicrob Agents Chemother. 2015;59(8):4734-4741.18. Vali L, Davies SE, Lai LLG, et al. Frequency of biocide resistance genes, antibiotic resistance, and the effect of chlorhexidine exposure on clinical methicillin-resistant Staphylococcus aureus isolates. J Antimicrob Chemother. 2008;61(3):524-532. 19. McKenna SM, Davies KJ. The inhibition of bacterial growth by hypochlorous acid. Possible role in the bactericidal activity of phagocytes. Biochem J. 1988;254(3):685-692. 20. Prevention and Treatment of Pressure Ulcers/Injuries: A Clinical Practice Guideline. http://www.internationalguideline.com/guideline. Accessed 11/26/2019. 21. International Wound Infection Institute (IWII): Wound infection in Clinical Practice, 2016, Wounds International. 22. Hiebert JM, Robson MC. The immediate and delayed post-debridement effects on tissue bacterial wound counts of hypochlorous acid versus saline irrigation in chronic wounds. Eplasty. 2016;16:e32. 23. Niezgoda JA, Sordi PJ, Hermans MH. Evaluation of Vashe Wound Therapy in the clinical management of patients with chronic wounds. Adv Skin Wound Care. 2010;23(8):352-357. 24. Miller C, Mouhlas A. Significant cost savings realized by changing debridement protocol. Ostomy Wound Manage. 2014;60(9):8-9. 25. Othman D. Negative pressure wound therapy literature review of efficacy, cost effectiveness, and impact on patients quality of life in chronic wound management and its implementation in the United Kingdom. Plast Surg Int. 2012;2012:374398. 26. Robson MC. Treating chronic wounds with hypochlorous acid disrupts biofilm. Todays Wound Clinic. 2014;8(9). 27. Felte R, Gallagher K. A case review series of negative pressure wound therapy with instillation and dwell time (NPWTi-d) using Hypochlorous acid (HOCl) versus Sodium hypochlorite (NaOCl) or 0.9% normal saline instillation in complex infected wounds. Poster Presentation: Symposium for Advanced Wound Care; San Diego, CA; April 2017. 28. Desvigne MN. Hypochlorous acid: A practical choice for instillation with negative pressure wound therapy when surgical closure is anticipated. Wound Manag Prev. 2020;66(3):8-11. 29. Fernandez L, Ellman C, Jackson P. Initial Experience Using a Novel Reticulated Open Cell Foam Dressing with Through Holes during Negative Pressure Wound Therapy with Instillation for Management of Pressure Ulcers. J Trauma Treat. 2017;6:410. 30. Boie B. Rapid wound bed preparation using NPWT with hypochlorous acid instillation. Ostomy Wound Manage. 2018;64(8):10,12. 31. James GA, Swogger E, Wolcott R, et al. Biofilms in chronic wounds. Wound Repair Regen. 2008;16(1):37-44. doi: 10.1111/j.1524-475X.2007.00321.x. 32. Foster KN, Tanner VL, Richey KJ, et al. Vashe wound therapy versus Sulfamylon in the management of grafted burns: results of a pilot study. Presented at the 42nd annual meeting of the American Burn Association, Boston, MA, 2010. 33. Foster KN, Gray D, Ostovar A, et al. Reduction of MRSA infectious complications in a burn center using a simple universal decolonization protocol. Presented as a poster at the Spring SAWC, San Antonio, TX, May, 2015. 34. Gray D, Foster K, Cruz A, et al. Universal decolonization with hypochlorous solution in a burn intensive care unit in a tertiary care community hospital. Am J Infect Control. 2016;44(9):1044-1046. 35. Foster KN, Richey KJ, Champagne JS, et al. Randomized comparison of hypochlorous acid with 5% sulfamylon solution as topical therapy following skin grafting. Eplasty. 2019;19:e16.Distributed by: Urgo Medical, LLC 2020 Urgo Medical North America.Fort Worth, TX 76107 All rights reserved.To order, call 1-855-888-8273 orVashe, Urgo and the Urgo logo are registered trademarks of Urgo Medical.visit www.urgomedical.us Item#201-LT011 Rev. 5/20'